MS → AL · about 259 miles
Biloxi to Opelika bus schedule
Greyhound runs 7 direct buses a week from Biloxi to Opelika. The fastest takes 6 hours 10 minutes; every bus leaves at 9:55 AM.
Timetable data from · No schedule changes since at least
- Buses a week
- 7
- Fastest trip
- 6h 10m
- Leaves at
- 9:55 AM
Timetable
Every bus leaves from Biloxi MS (BIG) and arrives at Opelika 4Th Street Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 9:55 AM | 4:05 PM | 6h 10m | Daily | Greyhound Full timetable |
Route map
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Where to board in Biloxi Where you get off in Opelika The route of the busiest trip
Where to catch the bus in Biloxi
Where the bus stops in Opelika
- Opelika 4Th Street Station Map of Opelika 4Th Street Station (Google Maps)
Return trip: Opelika to Biloxi
Questions
How long is the bus from Biloxi to Opelika?
The fastest direct bus takes 6 hours 10 minutes.
What time is the first bus from Biloxi to Opelika?
Every departure is at 9:55 AM (Daily).
Which bus companies go from Biloxi to Opelika?
Greyhound runs direct buses on this route.
Where do I catch the bus in Biloxi?
Buses to Opelika leave from Biloxi MS (BIG).