OH → IL · about 251 miles
Cincinnati to Chicago bus & train schedule
Amtrak and FlixBus run 11 direct buses and trains a week from Cincinnati to Chicago. The fastest takes 6 hours; the first departure leaves at 2:21 AM and the last at 1:40 PM.
Timetable data from · Schedule last changed
- Buses and trains a week
- 11
- Fastest trip
- 6h 00m
- First departure
- 2:21 AM
- Last departure
- 1:40 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 2:21 AM | 10:25 AM | 9h 04m | Mon, Thu, Sat | Cincinnati Union Terminal to Chicago Union Station | Amtrak Full timetable |
| 7:00 AM | 12:00 PM | 6h 00m | Daily except Tue | Cincinnati Cincinnati University of Cincinnati to Chicago Bus Station | FlixBus Full timetable |
| 1:40 PM | 6:55 PM | 6h 15m | Thu, Fri | Cincinnati Cincinnati University of Cincinnati to Chicago Bus Station | FlixBus Full timetable |
Route map
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Where to board in Cincinnati Where you get off in Chicago The route of the busiest trip
Where to board in Cincinnati
Where buses and trains stop in Chicago
Return trip: Chicago to Cincinnati
Questions
How long is the bus or train from Cincinnati to Chicago?
The fastest direct bus or train takes 6 hours; the typical trip is 9 hours 4 minutes.
What time is the first departure from Cincinnati to Chicago?
The earliest departure is at 2:21 AM (Mon, Thu, Sat) and the last at 1:40 PM (Thu, Fri).
Which bus and rail companies go from Cincinnati to Chicago?
Amtrak and FlixBus run direct buses and trains on this route.
Where do I board in Cincinnati?
Buses and trains to Chicago leave from Cincinnati Union Terminal and Cincinnati (Univ Of Cin).