MA → NY · about 396 miles
Boston to Buffalo bus & train schedule
Amtrak and Greyhound run 14 direct buses and trains a week from Boston to Buffalo. The fastest takes 10 hours 5 minutes; the first departure leaves at 12:30 PM and the last at 12:50 PM.
Timetable data from · Schedule last changed
- Buses and trains a week
- 14
- Fastest trip
- 10h 05m
- First departure
- 12:30 PM
- Last departure
- 12:50 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 12:30 PM | 10:35 PM | 10h 05m | Daily | Boston South Station to Buffalo | Greyhound Full timetable |
| 12:50 PM | 12:29 AM +1 day | 11h 39m | Daily | Boston to Buffalo Depew Station | Amtrak Full timetable |
Route map
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Where to board in Boston Where you get off in Buffalo The route of the busiest trip
Where to board in Boston
Where buses and trains stop in Buffalo
Return trip: Buffalo to Boston
Questions
How long is the bus or train from Boston to Buffalo?
The fastest direct bus or train takes 10 hours 5 minutes; the typical trip is 11 hours 39 minutes.
What time is the first departure from Boston to Buffalo?
The earliest departure is at 12:30 PM (Daily) and the last at 12:50 PM (Daily).
Which bus and rail companies go from Boston to Buffalo?
Amtrak and Greyhound run direct buses and trains on this route.
Where do I board in Boston?
Buses and trains to Buffalo leave from Boston (South Station).