MO → NY · about 875 miles
St. Louis to New York bus schedule
Greyhound runs 21 direct buses a week from St. Louis to New York. The fastest takes 24 hours 45 minutes; the first bus leaves at 2:00 AM and the last at 2:05 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 21
- Fastest trip
- 24h 45m
- First bus
- 2:00 AM
- Last bus
- 2:05 PM
Timetable
Every bus leaves from St Louis Bus Station and arrives at New York Manhattan 42 St Bus Terminal. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 2:00 AM | 4:20 AM +1 day | 25h 20m | Daily | Greyhound Full timetable |
| 8:45 AM | 10:30 AM +1 day | 24h 45m | Daily | Greyhound Full timetable |
| 2:05 PM | 3:55 PM +1 day | 24h 50m | Daily | Greyhound Full timetable |
Route map
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Where to board in St. Louis Where you get off in New York The route of the busiest trip
Where to catch the bus in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Where the bus stops in New York
Return trip: New York to St. Louis
Questions
How long is the bus from St. Louis to New York?
The fastest direct bus takes 24 hours 45 minutes; the typical trip is 24 hours 50 minutes.
What time is the first bus from St. Louis to New York?
The earliest departure is at 2:00 AM (Daily) and the last at 2:05 PM (Daily).
Which bus companies go from St. Louis to New York?
Greyhound runs direct buses on this route.
Where do I catch the bus in St. Louis?
Buses to New York leave from St Louis Bus Station.