MO → LA · about 600 miles
St. Louis to New Orleans bus schedule
Greyhound runs 7 direct buses a week from St. Louis to New Orleans. The fastest takes 16 hours 50 minutes; every bus leaves at 1:00 AM.
Timetable data from · No schedule changes since at least
- Buses a week
- 7
- Fastest trip
- 16h 50m
- Leaves at
- 1:00 AM
Timetable
Every bus leaves from St Louis Bus Station and arrives at New Orleans Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 1:00 AM | 5:50 PM | 16h 50m | Daily | Greyhound Full timetable |
Route map
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Where to board in St. Louis Where you get off in New Orleans The route of the busiest trip
Where to catch the bus in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Where the bus stops in New Orleans
- New Orleans Union Passenger Terminal Map of New Orleans Union Passenger Terminal (Google Maps)
Return trip: New Orleans to St. Louis
Questions
How long is the bus from St. Louis to New Orleans?
The fastest direct bus takes 16 hours 50 minutes.
What time is the first bus from St. Louis to New Orleans?
Every departure is at 1:00 AM (Daily).
Which bus companies go from St. Louis to New Orleans?
Greyhound runs direct buses on this route.
Where do I catch the bus in St. Louis?
Buses to New Orleans leave from St Louis Bus Station.