MO → KY · about 177 miles
St. Louis to Madisonville bus schedule
Greyhound runs 7 direct buses a week from St. Louis to Madisonville. The fastest takes 4 hours 55 minutes; every bus leaves at 1:45 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 7
- Fastest trip
- 4h 55m
- Leaves at
- 1:45 PM
Timetable
Every bus leaves from St Louis Bus Station and arrives at Madisonville KY (MDV). Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 1:45 PM | 6:40 PM | 4h 55m | Daily | Greyhound Full timetable |
Route map
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Where to board in St. Louis Where you get off in Madisonville The route of the busiest trip
Where to catch the bus in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Where the bus stops in Madisonville
- Madisonville KY (MDV) Map of Madisonville KY (MDV) (Google Maps)
Return trip: Madisonville to St. Louis
Questions
How long is the bus from St. Louis to Madisonville?
The fastest direct bus takes 4 hours 55 minutes.
What time is the first bus from St. Louis to Madisonville?
Every departure is at 1:45 PM (Daily).
Which bus companies go from St. Louis to Madisonville?
Greyhound runs direct buses on this route.
Where do I catch the bus in St. Louis?
Buses to Madisonville leave from St Louis Bus Station.