MO → MO · about 120 miles
St. Louis to Columbia bus schedule
Greyhound runs 21 direct buses a week from St. Louis to Columbia. The fastest takes 2 hours 25 minutes; the first bus leaves at 7:40 AM and the last at 5:15 PM.
Timetable data from · Schedule last changed
- Buses a week
- 21
- Fastest trip
- 2h 25m
- First bus
- 7:40 AM
- Last bus
- 5:15 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Bus company |
|---|---|---|---|---|---|
| 7:40 AM | 10:40 AM | 3h 00m | Daily | St Louis Bus Station to Columbia Wabash Station | Greyhound Full timetable |
| 12:30 PM | 3:05 PM | 2h 35m | Daily | St Louis Bus Station to Columbia Wabash Station | Greyhound Full timetable |
| 5:15 PM | 7:40 PM | 2h 25m | Daily | St Louis Bus Station to Columbia Midway Travel Plaza | Greyhound Full timetable |
Route map
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Where to board in St. Louis Where you get off in Columbia The route of the busiest trip
Where to catch the bus in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Where the bus stops in Columbia
Return trip: Columbia to St. Louis
Questions
How long is the bus from St. Louis to Columbia?
The fastest direct bus takes 2 hours 25 minutes; the typical trip is 2 hours 35 minutes.
What time is the first bus from St. Louis to Columbia?
The earliest departure is at 7:40 AM (Daily) and the last at 5:15 PM (Daily).
Which bus companies go from St. Louis to Columbia?
Greyhound runs direct buses on this route.
Where do I catch the bus in St. Louis?
Buses to Columbia leave from St Louis Bus Station.