SC → MD · about 421 miles
Spartanburg to Baltimore bus & train schedule
Amtrak and Greyhound run 28 direct buses and trains a week from Spartanburg to Baltimore. The fastest takes 11 hours 49 minutes; the first departure leaves at 3:04 AM and the last at 11:05 AM.
Timetable data from · Schedule last changed
- Buses and trains a week
- 28
- Fastest trip
- 11h 49m
- First departure
- 3:04 AM
- Last departure
- 11:05 AM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 3:04 AM | 2:53 PM | 11h 49m | Thu–Sun | Spartanburg Amtrak Station to Baltimore Penn Station | Amtrak Full timetable |
| 3:04 AM | 3:17 PM | 12h 13m | Mon–Fri | Spartanburg Amtrak Station to Baltimore Penn Station | Amtrak Full timetable |
| 3:30 AM New | 5:45 PM | 14h 15m | Daily | Spartanburg to Baltimore Downtown Bus Station | Greyhound Full timetable |
| 7:40 AM New | 8:05 PM | 12h 25m | Daily | Spartanburg to Baltimore Downtown Bus Station | Greyhound Full timetable |
| 11:05 AM New | 12:30 AM +1 day | 13h 25m | Daily | Spartanburg to Baltimore Downtown Bus Station | Greyhound Full timetable |
Route map
The map needs JavaScript.
Where to board in Spartanburg Where you get off in Baltimore The route of the busiest trip
Where to board in Spartanburg
Where buses and trains stop in Baltimore
Return trip: Baltimore to Spartanburg
Questions
How long is the bus or train from Spartanburg to Baltimore?
The fastest direct bus or train takes 11 hours 49 minutes; the typical trip is 12 hours 13 minutes.
What time is the first departure from Spartanburg to Baltimore?
The earliest departure is at 3:04 AM (Sat & Sun) and the last at 11:05 AM (Daily).
Which bus and rail companies go from Spartanburg to Baltimore?
Amtrak and Greyhound run direct buses and trains on this route.
Where do I board in Spartanburg?
Buses and trains to Baltimore leave from Spartanburg Amtrak Station and Spartanburg bus stop.