MD → SC · about 421 miles
Baltimore to Spartanburg bus & train schedule
Amtrak, FlixBus and Greyhound run 28 direct buses and trains a week from Baltimore to Spartanburg. The fastest takes 11 hours; the first departure leaves at 1:35 AM and the last at 8:55 PM.
Timetable data from · Schedule last changed
- Buses and trains a week
- 28
- Fastest trip
- 11h 00m
- First departure
- 1:35 AM
- Last departure
- 8:55 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 1:35 AM | 12:35 PM | 11h 00m | Daily | Baltimore Downtown Bus Station to Spartanburg | FlixBus Full timetable |
| 4:57 PM | 4:21 AM +1 day | 11h 24m | Daily from Dec 19 | Baltimore Penn Station to Spartanburg Amtrak Station | Amtrak Full timetable |
| 5:00 PM | 4:21 AM +1 day | 11h 21m | Daily | Baltimore Penn Station to Spartanburg Amtrak Station | Amtrak Full timetable |
| 5:00 PM | 6:30 AM +1 day | 13h 30m | Daily | Baltimore Downtown Bus Station to Spartanburg | Greyhound Full timetable |
| 5:05 PM | 4:21 AM +1 day | 11h 16m | Thu from Nov 26 | Baltimore Penn Station to Spartanburg Amtrak Station | Amtrak Full timetable |
| 8:55 PM | 10:15 AM +1 day | 13h 20m | Daily | Baltimore Downtown Bus Station to Spartanburg | Greyhound Full timetable |
Route map
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Where to board in Baltimore Where you get off in Spartanburg The route of the busiest trip
Where to board in Baltimore
Where buses and trains stop in Spartanburg
Return trip: Spartanburg to Baltimore
Questions
How long is the bus or train from Baltimore to Spartanburg?
The fastest direct bus or train takes 11 hours; the typical trip is 11 hours 21 minutes.
What time is the first departure from Baltimore to Spartanburg?
The earliest departure is at 1:35 AM (Daily) and the last at 8:55 PM (Daily).
Which bus and rail companies go from Baltimore to Spartanburg?
Amtrak, FlixBus and Greyhound run direct buses and trains on this route.
Where do I board in Baltimore?
Buses and trains to Spartanburg leave from Baltimore Penn Station and Baltimore (Downtown).