NC → SC · about 189 miles
Durham to Spartanburg bus schedule
FlixBus and Greyhound run 28 direct buses a week from Durham to Spartanburg. The fastest takes 4 hours 5 minutes; the first bus leaves at 1:35 AM and the last at 2:20 PM.
Timetable data from · Schedule last changed
- Buses a week
- 28
- Fastest trip
- 4h 05m
- First bus
- 1:35 AM
- Last bus
- 2:20 PM
Timetable
Every bus leaves from Durham W Pettigrew St Bus Station and arrives at Spartanburg. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 1:35 AM | 6:30 AM | 4h 55m | Daily | Greyhound Full timetable |
| 4:55 AM | 10:15 AM | 5h 20m | Daily | Greyhound Full timetable |
| 8:30 AM | 12:35 PM | 4h 05m | Daily | FlixBus Full timetable |
| 2:20 PM New | 7:45 PM | 5h 25m | Daily | Greyhound Full timetable |
Route map
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Where to board in Durham Where you get off in Spartanburg The route of the busiest trip
Where to catch the bus in Durham
Where the bus stops in Spartanburg
Return trip: Spartanburg to Durham
Questions
How long is the bus from Durham to Spartanburg?
The fastest direct bus takes 4 hours 5 minutes; the typical trip is 5 hours 20 minutes.
What time is the first bus from Durham to Spartanburg?
The earliest departure is at 1:35 AM (Daily) and the last at 2:20 PM (Daily).
Which bus companies go from Durham to Spartanburg?
FlixBus and Greyhound run direct buses on this route.
Where do I catch the bus in Durham?
Buses to Spartanburg leave from Durham W Pettigrew St Bus Station.