FL → FL · about 138 miles
Orlando to Lake City bus schedule
Greyhound runs 7 direct buses a week from Orlando to Lake City. The fastest takes 3 hours 45 minutes; every bus leaves at 5:15 AM.
Timetable data from · No schedule changes since at least
- Buses a week
- 7
- Fastest trip
- 3h 45m
- Leaves at
- 5:15 AM
Timetable
Every bus leaves from Orlando Bus Station and arrives at Lake City Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 5:15 AM | 9:00 AM | 3h 45m | Daily | Greyhound Full timetable |
Route map
The map needs JavaScript.
Where to board in Orlando Where you get off in Lake City The route of the busiest trip
Where to catch the bus in Orlando
Where the bus stops in Lake City
- Lake City Bus Station Map of Lake City Bus Station (Google Maps)
Questions
How long is the bus from Orlando to Lake City?
The fastest direct bus takes 3 hours 45 minutes.
What time is the first bus from Orlando to Lake City?
Every departure is at 5:15 AM (Daily).
Which bus companies go from Orlando to Lake City?
Greyhound runs direct buses on this route.
Where do I catch the bus in Orlando?
Buses to Lake City leave from Orlando Bus Station.