LA → MS · about 187 miles
Lafayette to Biloxi bus schedule
FlixBus and Greyhound run 13 direct buses a week from Lafayette to Biloxi. The fastest takes 4 hours 5 minutes; the first bus leaves at 2:25 AM and the last at 5:25 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 13
- Fastest trip
- 4h 05m
- First bus
- 2:25 AM
- Last bus
- 5:25 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Bus company |
|---|---|---|---|---|---|
| 2:25 AM | 6:30 AM | 4h 05m | Daily except Wed | Lafayette La to Biloxi MS (BIG) | FlixBus Full timetable |
| 5:25 PM | 10:20 PM | 4h 55m | Daily | Lafayette Transit System to Biloxi MS (BIG) | Greyhound Full timetable |
Route map
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Where to board in Lafayette Where you get off in Biloxi The route of the busiest trip
Where to catch the bus in Lafayette
Where the bus stops in Biloxi
Return trip: Biloxi to Lafayette
Questions
How long is the bus from Lafayette to Biloxi?
The fastest direct bus takes 4 hours 5 minutes.
What time is the first bus from Lafayette to Biloxi?
The earliest departure is at 2:25 AM (Daily except Wed) and the last at 5:25 PM (Daily).
Which bus companies go from Lafayette to Biloxi?
FlixBus and Greyhound run direct buses on this route.
Where do I catch the bus in Lafayette?
Buses to Biloxi leave from Lafayette FlixBus bus stop and Lafayette Amtrak Station.