FL → FL · about 65 miles
Key Largo to Big Pine Key bus schedule
Greyhound runs 19 direct buses a week from Key Largo to Big Pine Key. The fastest takes 2 hours 10 minutes; the first bus leaves at 6:30 AM and the last at 12:25 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 19
- Fastest trip
- 2h 10m
- First bus
- 6:30 AM
- Last bus
- 12:25 PM
Timetable
Every bus leaves from Key Largo Bus Stop and arrives at Big Pine Key. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 6:30 AM | 8:40 AM | 2h 10m | Daily | Greyhound Full timetable |
| 9:25 AM | 11:40 AM | 2h 15m | Mon, Tue, Fri, Sat, Sun | Greyhound Full timetable |
| 12:25 PM | 2:40 PM | 2h 15m | Daily | Greyhound Full timetable |
Route map
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Where to board in Key Largo Where you get off in Big Pine Key The route of the busiest trip
Where to catch the bus in Key Largo
- Key Largo Bus Stop Map of Key Largo Bus Stop (Google Maps)
Where the bus stops in Big Pine Key
- Big Pine Key Greyhound bus stop Map of Big Pine Key Greyhound bus stop (Google Maps)
Return trip: Big Pine Key to Key Largo
Questions
How long is the bus from Key Largo to Big Pine Key?
The fastest direct bus takes 2 hours 10 minutes; the typical trip is 2 hours 15 minutes.
What time is the first bus from Key Largo to Big Pine Key?
The earliest departure is at 6:30 AM (Daily) and the last at 12:25 PM (Daily).
Which bus companies go from Key Largo to Big Pine Key?
Greyhound runs direct buses on this route.
Where do I catch the bus in Key Largo?
Buses to Big Pine Key leave from Key Largo Bus Stop.