CA → CA · about 79 miles
Santa Ana to San Diego bus & train schedule
Amtrak and Greyhound run 105 direct buses and trains a week from Santa Ana to San Diego. The fastest takes 1 hour 45 minutes; the first departure leaves at 7:01 AM and the last at 11:01 PM.
Timetable data from · Schedule last changed
- Buses and trains a week
- 105
- Fastest trip
- 1h 45m
- First departure
- 7:01 AM
- Last departure
- 11:01 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 7:01 AM | 8:49 AM | 1h 48m | Daily | Santa Ana to San Diego Old Town Transportation Center | Amtrak Full timetable |
| 8:01 AM | 9:52 AM | 1h 51m | Daily | Santa Ana to San Diego Old Town Transportation Center | Amtrak Full timetable |
| 9:01 AM | 10:52 AM | 1h 51m | Daily | Santa Ana to San Diego Old Town Transportation Center | Amtrak Full timetable |
| 10:00 AM | 11:45 AM | 1h 45m | Daily | Santa Ana East Santa Ana Boulevard 1000 to San Diego Greyhound Bus Stop | Greyhound Full timetable |
| 11:01 AM | 12:52 PM | 1h 51m | Daily | Santa Ana to San Diego Old Town Transportation Center | Amtrak Full timetable |
| 12:01 PM | 1:52 PM | 1h 51m | Daily | Santa Ana to San Diego Old Town Transportation Center | Amtrak Full timetable |
| 1:01 PM | 2:52 PM | 1h 51m | Daily | Santa Ana to San Diego Old Town Transportation Center | Amtrak Full timetable |
| 4:01 PM | 5:52 PM | 1h 51m | Daily | Santa Ana to San Diego Old Town Transportation Center | Amtrak Full timetable |
| 5:01 PM | 6:52 PM | 1h 51m | Daily | Santa Ana to San Diego Old Town Transportation Center | Amtrak Full timetable |
| 6:01 PM | 7:52 PM | 1h 51m | Daily | Santa Ana to San Diego Old Town Transportation Center | Amtrak Full timetable |
| 7:01 PM | 8:52 PM | 1h 51m | Daily | Santa Ana to San Diego Old Town Transportation Center | Amtrak Full timetable |
| 8:01 PM | 9:52 PM | 1h 51m | Daily | Santa Ana to San Diego Old Town Transportation Center | Amtrak Full timetable |
| 9:01 PM | 10:51 PM | 1h 50m | Daily | Santa Ana to San Diego Old Town Transportation Center | Amtrak Full timetable |
| 10:05 PM | 11:50 PM | 1h 45m | Daily | Santa Ana East Santa Ana Boulevard 1000 to San Diego Greyhound Bus Stop | Greyhound Full timetable |
| 11:01 PM | 12:50 AM +1 day | 1h 49m | Daily | Santa Ana to San Diego Old Town Transportation Center | Amtrak Full timetable |
Route map
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Where to board in Santa Ana Where you get off in San Diego The route of the busiest trip
Where to board in Santa Ana
- Santa Ana East Santa Ana Boulevard 1000 Map of Santa Ana East Santa Ana Boulevard 1000 (Google Maps)
Where buses and trains stop in San Diego
Return trip: San Diego to Santa Ana
Questions
How long is the bus or train from Santa Ana to San Diego?
The fastest direct bus or train takes 1 hour 45 minutes; the typical trip is 1 hour 51 minutes.
What time is the first departure from Santa Ana to San Diego?
The earliest departure is at 7:01 AM (Daily) and the last at 11:01 PM (Daily).
Which bus and rail companies go from Santa Ana to San Diego?
Amtrak and Greyhound run direct buses and trains on this route.
Where do I board in Santa Ana?
Buses and trains to San Diego leave from Santa Ana East Santa Ana Boulevard 1000.