CA → CA · about 79 miles
San Diego to Santa Ana bus & train schedule
Amtrak and Greyhound run 105 direct buses and trains a week from San Diego to Santa Ana. The fastest takes 1 hour 35 minutes; the first departure leaves at 4:01 AM and the last at 9:01 PM.
Timetable data from · No schedule changes since at least
- Buses and trains a week
- 105
- Fastest trip
- 1h 35m
- First departure
- 4:01 AM
- Last departure
- 9:01 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 4:01 AM | 5:59 AM | 1h 58m | Daily | San Diego to Santa Ana | Amtrak Full timetable |
| 5:40 AM | 7:35 AM | 1h 55m | Daily | San Diego Greyhound Bus Stop to Santa Ana East Santa Ana Boulevard 1000 | Greyhound Full timetable |
| 6:01 AM | 8:02 AM | 2h 01m | Daily | San Diego to Santa Ana | Amtrak Full timetable |
| 7:01 AM | 9:02 AM | 2h 01m | Daily | San Diego to Santa Ana | Amtrak Full timetable |
| 8:01 AM | 10:02 AM | 2h 01m | Daily | San Diego to Santa Ana | Amtrak Full timetable |
| 10:01 AM | 12:02 PM | 2h 01m | Daily | San Diego to Santa Ana | Amtrak Full timetable |
| 12:01 PM | 2:02 PM | 2h 01m | Daily | San Diego to Santa Ana | Amtrak Full timetable |
| 1:01 PM | 3:02 PM | 2h 01m | Daily | San Diego to Santa Ana | Amtrak Full timetable |
| 2:01 PM | 4:02 PM | 2h 01m | Daily | San Diego to Santa Ana | Amtrak Full timetable |
| 4:01 PM | 6:02 PM | 2h 01m | Daily | San Diego to Santa Ana | Amtrak Full timetable |
| 5:01 PM | 7:04 PM | 2h 03m | Daily | San Diego to Santa Ana | Amtrak Full timetable |
| 7:01 PM | 9:02 PM | 2h 01m | Daily | San Diego to Santa Ana | Amtrak Full timetable |
| 7:45 PM | 9:20 PM | 1h 35m | Daily | San Diego Greyhound Bus Stop to Santa Ana East Santa Ana Boulevard 1000 | Greyhound Full timetable |
| 8:01 PM | 10:02 PM | 2h 01m | Daily | San Diego to Santa Ana | Amtrak Full timetable |
| 9:01 PM | 10:59 PM | 1h 58m | Daily | San Diego to Santa Ana | Amtrak Full timetable |
Route map
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Where to board in San Diego Where you get off in Santa Ana The route of the busiest trip
Where to board in San Diego
Where buses and trains stop in Santa Ana
- Santa Ana East Santa Ana Boulevard 1000 Map of Santa Ana East Santa Ana Boulevard 1000 (Google Maps)
Return trip: Santa Ana to San Diego
Questions
How long is the bus or train from San Diego to Santa Ana?
The fastest direct bus or train takes 1 hour 35 minutes; the typical trip is 2 hours 1 minute.
What time is the first departure from San Diego to Santa Ana?
The earliest departure is at 4:01 AM (Daily) and the last at 9:01 PM (Daily).
Which bus and rail companies go from San Diego to Santa Ana?
Amtrak and Greyhound run direct buses and trains on this route.
Where do I board in San Diego?
Buses and trains to Santa Ana leave from San Diego Amtrak station and San Diego Old Town-FlixBus.